Affected person Dies Weeks After Kidney Transplant From Genetically Modified Pig
Richard “Rick” Slayman, who made historical past at age 62 as the primary particular person to obtain a kidney from a genetically modified pig, has died about two months after the process.
Massachusetts Normal Hospital, the place Mr. Slayman had the operation, mentioned in a assertion on Saturday that its transplant staff was “deeply saddened” at his dying. The hospital mentioned it had “no indication that it was the results of his latest transplant.”
Mr. Slayman, who was Black, had end-stage kidney illness, a situation that impacts greater than 800,000 individuals in the US, in accordance with the federal authorities, with disproportionately increased charges amongst Black individuals.
There are far too few kidneys out there for donation. Almost 90,000 persons are on the nationwide ready checklist for a kidney.
Mr. Slayman, a supervisor for the state transportation division from Weymouth, Mass., had acquired a human kidney in 2018. When it started to fail in 2023 and he developed congestive coronary heart failure, his medical doctors urged he attempt one from a modified pig.
“I noticed it not solely as a method to assist me, however a method to supply hope for the 1000’s of people that want a transplant to outlive,” he mentioned in a hospital information launch in March.
His surgical procedure, which lasted 4 hours, was a medical milestone. For many years, proponents of so-called xenotransplantation have proposed changing ailing human organs with these from animals. The primary drawback with the method is the human immune system, which rejects animal tissue as overseas, typically resulting in severe issues.
Current advances in genetic engineering have allowed researchers to tweak the genes of the animal organs to make them extra suitable with their recipients.
The pig kidney that was transplanted into Mr. Slayman was engineered by eGenesis, a biotech firm primarily based in Cambridge, Mass. Scientists there eliminated three genes and added seven others to enhance compatibility. The corporate additionally inactivated retroviruses that pigs carry and may very well be dangerous to people.
“Mr. Slayman was a real pioneer,” eGenesis mentioned in a assertion on social media on Saturday. “His braveness has helped to forge a path ahead for present and future sufferers affected by kidney failure.”
Mr. Slayman was discharged from the hospital two weeks after his surgical procedure, with “one of many cleanest payments of well being I’ve had in a very long time,” he mentioned on the time.
In a press release printed by the hospital, Mr. Slayman’s household mentioned he was sort, quick-witted and “fiercely devoted to his household, mates and colleagues.” They mentioned that they had taken nice consolation in figuring out that his case had impressed so many individuals.
“Thousands and thousands of individuals worldwide have come to know Rick’s story,” they mentioned within the assertion. “We felt — and nonetheless really feel — comforted by the optimism he offered sufferers desperately ready for a transplant.”
